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D63.1 is Anemia in chronic kidney disease and requires a CKD code sequenced first

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Several important factors warrant consideration: Concurrent medications and supplements frequently contribute to gastrointestinal symptoms

When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)