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tirzepatide is a dual agonist that acts on two pathways (GIP and GLP-1)
This PTM also occurs in mitochondria, regulating the OXPHOS and other mitochondrial functions [166]
It also plays a massive role in reducing the formation of thick, inflexible scar tissue [3, 6]
While the long-term consequences of GLP-1 receptor agonism are now emerging, similar long-term studies will be required to investigate the safety of new co-agonists in the brain and cardiovascular system, and their potential for promoting cell proliferation [39]
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This multi-receptor approach distinguishes retatrutide from earlier agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GLP-1 and GIP receptor agonist)
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