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These deposits disrupt the structure and function of cells 9

Injectable routes carry a particular concern for immunogenicity from peptide aggregation and impurities, and FDA noted the available certificates of analysis for AOD-9604 bulk drug substances did not consistently control for impurities, aggregates, or microbial limits

Useful oxidative-damage markers may include urinary 8-OHdG , which reflects oxidative DNA damage, and lipid peroxides , which reflect oxidative damage to fats and cell membranes

As a regenerative approach that does not require transplanting live cells, EVs therapy may directly target the root mechanisms of ovarian dysfunction, mitochondrial failure, reactive oxygen species (ROS) accumulation, and inflammation, rather than merely alleviating downstream symptoms (Luo et al., 2024