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Conjugation of GSH with electrophilic compounds is mainly mediated by the glutathione- S -transferases (GSTs), a super family of Phase II detoxification enzymes

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Most clinicians pair the stack with specific rehab work physical therapy for tendon or ligament injuries, anti-inflammatory diet changes for gut issues, or graded return-to-activity programs for post-surgical patients

As acetyl-CoA stores are depleted, the synthesis of NAGA an important cofactor of CPS I from acetyl-CoA and glutamate by NAGA synthetase is decreased

This flexibility appeals to patients who are sensitive to medication changes or who want more granular control over their treatment