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Advances in structural biologyparticularly the integration of AlphaFold and RoseTTAFoldhave enabled rational drug design targeting key ferroptosis effectors such as ACSL4, LOXs, and system Xc components
Musculoskeletal Research: Studied in tendon, ligament, and muscle injury models, where it has been linked with improved angiogenesis and repair responses
8-hydroxy-2-deoxyguanosine is a widely recognized biomarker of oxidative stress
LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis
