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These include attenuation of inflammatory responses by downregulating adhesion molecules and pro-inflammatory cytokines, inhibition of macrophage infiltration and foam cell formation, and modulation of lipid metabolism

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However, this is a US-based observational study, and newer GLP-1s are expensive treatments, meaning there may well be some important differences between the people taking GLP-1s and those not taking them that may not be fully controlled for

The TRIUMPH-4 trial also ran 8 weeks longer than GLORY-2, giving retatrutide more time to produce results

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