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Presented for research literature review only Zavaleta-Monestel E et al

The docking analyses revealed that the positioning of the GSH-thiolate in relation to C-2 and O-3 of the docked substrates could enable an acidbase mechanism of dehydration or tautomerization, in which the GSH cofactor acts as a proton-relay system (Fig

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Additionally, the model assumed constant transition probabilities over the 25-year horizon, which may not fully capture the time-varying nature of complication risks as patients age and disease progresses, potentially introducing minor biases in long-term complication rate estimations

2012;344(jun13 2):e3412-e3412