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NCT04847557) seeks to evaluate the effect of tirzepatide (is a dual agonist for the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors) over 52 weeks in 700 patients with heart failure with preserved ejection fraction (HFpEF) and obesity
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Currently, their use in Parkinson's remains experimental, with no NHS or NICE recommendation outside of clinical trials
The FDA-approved Mounjaro and Zepbound pens carry similar in-use labels
together, these modifications extend the elimination half-life to ~160 h and allow once-weekly dosing [22, 23]
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