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Glucagon Thermogenesis GLP Diabetes Care 2023 View on PubMed GIP Receptor Agonism: Beyond Insulin Secretion to Adipose Tissue Remodeling Finding: GIP receptor (GIPR) activation was found to have direct effects on adipose tissue: improved fat storage efficiency (reduced ectopic fat), enhanced insulin sensitivity in adipocytes, and modulation of adipokine secretion (increased adiponectin, reduced resistin)

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Both reviewers went over each study independently by their titles, abstracts, and other criteria to determine inclusion for further analysis or not as the first screening

An efficacious treatment for AD has not been forthcoming in part due to the large numbers of potentially important biomarkers, the difficulty in determining their diagnostic reliability and validity, and the multifactorial characteristics of the disease process