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hence, considering that an imbalance in the microbiota correlates with chronic inflammation pathologies of the bowel, or even Type 2 diabetes, it is likely that dietary components indirectly influence the occurrence of these pathologies via the microbiota (390, 391)
Inclusion criteria were age 18 years, BMI of 2535 kg/m 2 , prediabetes (impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT)) using the American Diabetes Association criteria [17] and a stable body weight for 3 months prior to the study
SGLT2 inhibitors, including dapagliflozin, empagliflozin, and canagliflozin, are oral medications taken once daily
These medications carry an FDA boxed warning for medullary thyroid carcinoma and are contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2
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