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Abstract Providing NO-system importance, we suggest that one single application of the NOS-blocker L-NAME may induce retinal ischemia in rats, and that the stable pentadecapeptide BPC 157 may be the therapy, since it may interact with the NO-system and may counteract various adverse effects of L-NAME application

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These effects have been attributed to improvements in insulin sensitivity, modulation of lipid metabolism, and activation of enteroendocrine and thermogenic gene programs

J Biotechnol 188:112121