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The Wegovy pill, approved in December 2025, is the first oral GLP-1 medication formally indicated for chronic weight management in adults
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Subjects were excluded if they had clinically significant concomitant diseases or disorders, clinically significant abnormal values in laboratory screening tests, any history of gastrointestinal surgery (except uncomplicated surgical procedures such as appendectomy and hernia surgery), or if they smoked more than five cigarettes or the equivalent per day
These types of studies establish confidence in the outcomes, as neither the scientists nor the participants are aware of who receives actual medication versus a placebo during the trial
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