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In an exploratory analysis of REWIND, the hazard of substantive cognitive impairment was reduced by 14% in the dulaglutide group [62]
A practical, three-step approach adapted from current World Health Organization (56), American College of Sports Medicine (57), American Diabetes Association (58), and European Association for the Study of Obesity (59) guidelines is recommended: (1) introduce regular movement gradually, targeting 150 minutes of moderate-intensity or 75 minutes of vigorous aerobic activity per week (60)
It targets GLP-1, GIP, and glucagon receptors, showing promising results for weight loss, blood sugar control, and overall metabolic health