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The SURPASS-CVOT trial examining tirzepatide's cardiovascular outcomes is ongoing, and results are expected to inform future labeling
Pregnant or breastfeeding individuals should avoid lipotropic injections due to insufficient safety data on high-dose methionine and choline during gestation
The article's table lists TSH and free T4 every 6 to 8 weeks initially for people on levothyroxine, and every 4 to 6 weeks for thyroiditis or post-thyroidectomy patients
It possesses in vitro balanced GIPR (EC50 = 3 pM) and GLP-1R (EC50 = 5 pM) agonism with relative activity seven times that of GIP to GIPR and five times that of GLP-1 to GLP-1R, respectively (44)
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