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The damage caused by SAP to the vascular endothelium is manifested as the release of inflammatory mediators and leukocyte adhesion, increased vascular permeability, changes in blood flow shear stress, microthrombosis, and microcirculatory disorders
10.1038/mp.2016.33 281
And as a consequence, markers of tissue inflammation also increase as we age because you're sort of removing this anti-inflammatory compound that's released each night
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