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Once levels stabilize, injections are commonly spaced out to monthly or every few months
The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )
If you reconstitute a vial and see clear solution, either the B12 was omitted or the concentration is extremely low
TB-500 also appears to be generally well-tolerated, but again, safety data derived from adequately powered clinical trials is lacking
The lack of preservative means bacterial growth becomes a concern quickly
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