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Nrf2/Keap1/ARE Redox Regulatory Pathway In response to oxidative or xenobiotic stress, Nrf2 dissociates from its inhibitor Keap1, translocates to the nucleus, and binds antioxidant response elements (ARE) to induce expression of genes involved in antioxidant defense and GSH biosynthesis (41)

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We summarize the impact of GLP-1RAs on immune cell biology and discuss their potential contributions to autoimmune and autoinflammatory diseases by regulating immune responses (Table 2)