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On the other hand, extended sleep duration, often observed in atypical depression, may also alter circadian rhythm, which is important for metabolic health, reduce physical activity, and worsen insulin sensitivity, complicating glycemic control [51, 52]

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(FYI, participants were not on any other diabetes medications at the start of the trial.) Participants also had an average weight loss of 4.5%7.6% over the same period, with those who took higher doses experiencing the higher end of the range of weight loss