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A dedicated cardiovascular outcomes trial (CVOT) for orforglipron has not been mandated by the FDA for initial approval but may be required or conducted voluntarily as a post-marketing commitment, following the precedent set by the SELECT trial for semaglutide
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in turn, this could lessen oxidative stress, explains the JISSN article
Furthermore, it was recently reported that use of GLP-1RAs for more than 6 months increased the risk of neovascular age-related macular degeneration (nAMD) by about twofold, although the association between a gastric inhibitory polypeptide (GIP)/GLP-1 receptor dual agonist (GIP/GLP-1RA) and nAMD is not clearly established
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