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GLP-1 Therapies and Risk of Muscle Loss Glucagon-like peptide-1 (GLP-1) medications have increasingly been prescribed to treat cardiometabolic conditions such as obesity, diabetes, and cardiovascular diseasesYeo et al (2024) conducted a nationwide analysis on the usage of GLP-1's in patients without diabetes and observed a 700% (from 21,000 in 2019 to 174,000 in 2023) increase between the years 2019-2023
Balanced meals with protein, fiber and healthy fats help GLP-1 signaling work effectively
One small study showed morning dosing may offer about 15% better post-prandial glucose control, but the more impactful consideration is whether morning or evening timing better manages your side effects and aligns with your routine
Indeed, a negative association between caffeine and tannins with serum folate levels has been reported in a study of pregnant Japanese women consuming caffeinated beverages such as coffee and/or green/oolong teas (Otake et al, 2018)
Another reader shared these thoughts about weight loss medications: Doctors need to make sure their patients know about muscle loss and prescribe strength training and adequate protein intake when prescribing GLP-1 drugs
