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Numerous toxicity studies have been done to assess the safety of MSM and doses up to 4,845.6 mg per day (4.8 grams) appear to be safe ( However, some people may experience mild reactions if they are sensitive to MSM, such as stomach issues like nausea, bloating and diarrhea
Most researchers find the 8mg to 12mg transition more manageable than the 4mg to 8mg transition, possibly because the GI system has already adapted to substantial receptor agonism
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Because of these limitations, there was a desire for a GLP-1 agonist that could be taken orally at any time of the day without any food or water restrictions
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