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A, Cumulative food intake (grams) up to 8 h after ICV injection of GLP-1, OXM, glucagon, or glicentin (all 3 nmol) into fasted animals
Large portions are also problematic because gastric emptying is slowed smaller, more frequent meals work better
Best taken first thing in the morning
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Metabolic unpredictability: Simultaneously altering multiple metabolic pathways incretin signalling, glucagon activity, and NAD+ metabolism without clinical oversight introduces unpredictable physiological consequences
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