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[4] Elevated NAD+ acts as a co-substrate for sirtuins, specifically activating SIRT1 often called the longevity gene. SIRT1 activation drives increased mitochondrial biogenesis and metabolic rate
Maintenance therapy has a different approach, where you take 100-200 mcg once a month
How to interpret vitamin B6 tests: Plasma pyridoxal-5'-phosphate (PLP) is considered the best way to assess vitamin B6 status in people without inflammatory conditions---it is the active form of B6 in the body and not strongly influenced by daily fluctuations in B6 intake
As the levels find their equilibrium, these signs usually dissipate within a span of a few days to a couple of weeks
This places them at elevated risk for B12 deficiency, and standard oral supplementation may not provide adequate absorption
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