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Increased cAMP/PKA activity and associated signaling accelerate nucleotide excision repair (NER), reduce UVinduced cyclobutane pyrimidine/thymine dimers, and bolster antioxidant defenses, thereby decreasing genotoxic burden after UV exposure
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By now Holst had joined them as a consultant (Molteni, Chen)
Up-regulation of EGR-1 and cyclin D1 A bit more technical: EGR-1 (Early Growth Response 1) and cyclin D1 are transcription factors, proteins that, in the cells nucleus, determine which genes are switched on
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