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PMID: 29049653
Key exclusion criteria were type 1 diabetes, eGFR 10% weight loss
53 Under the IRAs framework, there is a fundamental incentive distortion between small molecules and biologics: Small Molecules: Subject to price negotiation 9 years after approval
A recent publication describes similar results with broad ActRIIA/B receptor blockade during GLP-1 RA-induced weight loss in obese mice, i.e., prevention of muscle loss with increased fat loss, resulting in multiple metabolic benefits 45
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