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Nguyen and Kochevar 22 reported a biphasic effect of humidity on pigmentation: skin coloration increased with humidity levels up to 75% but decreased at higher levels, particularly under occlusion, suggesting that optimal humidity levels are crucial for tanning
"Lysine-alpha-ketoglutarate reductase and saccharopine dehydrogenase are located only in the mitochondrial matrix in rat liver"
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The molecule was initially developed for use as a sunless tanning agent and has since undergone extensive clinical study
D: Silymarin at 280 mg/kg of food
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