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Caution is advised in patients with severe gastrointestinal disease, a history of pancreatitis, or severe renal impairment
However, animal studies indicate that they could be harmful to the developing fetus
While no studies show cancer causation, those with a history of cancer should avoid these compounds due to IGF-1s mitogenic properties
NR supplementation increased NAD + levels and improved clinical symptoms, suggesting NRs potential as a safe therapeutic strategy for PD patients
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