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This interaction may lead to upregulated hunger hormone signals, as observed by scientists such as Lall et al., who have observed over a 15% increase in size and weight in laboratory models
Administration of spironolactone, a selective MR antagonist, counteracted stress-induced mGlu2 suppression and the related development of depressive-like behavior, implicating rapid action of glucocorticoids via a receptor that is known to modulate glutamate release [20]