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Results The metabolic rate of GLP-1R KO mice was significantly slower than that of WT mice ( p = 0.0345, WT mice 0.02335 0.057 mM/min, GLP-1R KO mice 0.01998 0.07 mM/min)

We have previously reported a simple PK model for depot-based biopharmaceutical formulations following SC administration, including in PNP hydrogels, based on a two-compartment model that takes into account species-relevant dosing and physiological values for GLP-1 RA PK (Figure 7A) ( 57 )

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For insulin used with a Medicare-covered durable medical-equipment pump, the Part B coinsurance cap of $35 for a one-month supply and deductible waiver began July 1, 2023