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If you are taking insulin or a sulfonylurea alongside retatrutide, be aware of the signs of hypoglycaemia (low blood sugar) including shakiness, sweating, confusion, and palpitations and discuss a management plan with your clinical team before your first dose
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Proinflammatory cytokines also play a crucial role in diabetes-related cognitive decline
While semaglutide targets only GLP-1 receptors, tirzepatide is a dual agonist that targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, adding a second metabolic pathway to the mechanism
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