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Consider the indication for which your patient is being initiated on warfarin and how quickly/slowly you need to achieve therapeutic status If we say the average risk of stroke in a patient with atrial fibrillation is ~5% per year (not accounting for CHADSVASC scores and risk stratification), then the daily risk of stroke per day is ~0.014%

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Samples were reconstituted in 90 l of 50% acetonitrile (Fisher Scientific, A955) and transferred to glass vials for LCMS analysis

PMID 19960212