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We have shown that only diets containing high ratios of n-3:n-6 (10:1 and 25:1) inhibited carcinogenesis, inhibited NF-B ,and activated PPAR in mammary adenocarcinomas induced by N -methyl- N -nitrosourea (MNU) in the rat 7
Its short halflife and rapid turnover make it a dynamic biomarker for cellular redox status
The fibrotic process is a dysregulated wound-healing response, driven by the persistent activation of fibroblasts (or myofibroblasts), which results in the deposition of excessive extracellular matrix (ECM) proteins such as collagen [4], a key feature of pathological tissue remodelling in fibrotic disorders [5,6,7,8]
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