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Thats why the ADA says social determinants of health (SDOH) should be assessed for everyone with diabetes to connect them with available help and resources
10.1016/j.trci.2018.06.014 155 KleinA
Weight loss results: 5mg group: 16.0% body weight reduction 10mg group: 21.4% body weight reduction 15mg group: 22.5% body weight reduction Placebo: 3.1% body weight reduction These weight losses require sustained, significant appetite reduction
However, one theory suggests that Ozempic, like other medications, can alter the balance of chemicals in the brain, which could potentially lead to mood changes or depression
These nonlinear, dose-dependent, and circuit-dependent interactions underscore the vulnerability of PDE10A modulation to background dopaminergic signal and highlight a key translational barrier: balanced activation of striatal medium spiny neuron (MSN) pathways observed in rodents does not reliably predict therapeutic outcomes in patients with chronic D 2 blockade and altered corticostriatal network dynamics (Gentzel et al., 2015)
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