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Male rodents are frequently used in the VPA-induced ASD model because male animals often display more consistent behavioral alterations in this model (Kazlauskas et al., 2019
As a retrospective cohort analysis, it is inherently subject to biases such as selection bias
While mediation analyses suggest that improved glycemic control, weight loss, and reduced blood pressure contribute to these benefits, they likely do not fully explain the observed renoprotection [36,37,38]
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