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Studies have confirmed that TMAO plays an important role in inducing foam cell formation and vascular inflammation by up-regulating the MAPK/JNK pathway and MAPK/ERK pathway (Geng et al., 2018
however, repeated injections and anesthesia may prove harmful
These models were genetically or chemically altered to mimic the protein accumulations of Alzheimers disease
Some researchers prefer an alternative method
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