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The constant levels of marker proteins such as GAPDH, combined with observations indicating that knockdown of the UPR element, BiP/Grp78 , revealed no detectable effects on Nrf2, GCLC, or glutathione, further support the conclusion that NFT-mediated stabilization of Nrf2 is a major contributor to its accumulation and the subsequent stimulation of GCL and glutathione synthesis

Lancet Glob Health 12:e1534e1543

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Methods Samples used to determine sub-visible particle count were stored at stressed conditions, defined as: Duration: 42 days Temperature: 30C 2C Stress condition: During storage, samples were inverted 360 to simulate patient use out of refrigerated storage