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UK Prospective Diabetes Study (UKPDS) Grou

Notably, microbial alterations associated with steroid hormone synthesis regulation exhibited gender-specific differences: male patients showed increased Clostridium and Fusobacterium , while female patients demonstrated a significant rise in Prevotella

Diarrhea affects some patients, particularly in the first few weeks at a new dose

Individual response varies based on genetic factors, baseline metabolic health, and medication tolerance