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Using in silico design, structureactivity relationships (SARs), chemical optimization, cell-based assays and in vivo experiments, we identified and characterized the first-in-kind small-molecule inhibitors of STX7Munc13-4-dependent endosomal maturation and signaling for use in immune cells that contribute to systemic inflammation
How Genetic Predispositions Shape GLP-1 Selection Genetic factors in peptide signaling pathwayssuch as variants in GIPR and FTO, and MC4R genescan provide context about your baseline metabolic regulation and may inform initial medication selection
Davidson, N
The FDA (Food and Drug Administration) ruled that those participating in coffee enema studies be warned of the risk of death
Diabetes Ther 12 , 879896 (2021)
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