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3.1.1 Topoisomerase inhibitors Topoisomerase inhibitors are a class of anticancer drugs whose mechanism of action is based on blocking topoisomerase enzymes from re-ligating the DNA strands after supercoiling, thus preventing DNA replication [61]

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In contrast, KD, defined by high-fat, very low-carbohydrate, and moderate protein intake, induces a state of nutritional ketosis with elevated circulating ketone bodies, including -hydroxybutyrate

Retatrutide was found to inhibit the HBP, thereby preventing YAP O-GlcNAcylation and promoting its degradation

Green R et al