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Presented for research literature review only Winterbourn CC (2019)

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According to clinical trials, prescription GLP-1 medications typically lead to 518% weight loss, while studies of high-dose tirzepatide combined with intensive lifestyle support have reported reductions of up to ~25%

Glucagon-like peptide 1 and its cleavage products are renoprotective in murine diabetic nephropathy

This intense inflammation is associated with damaging systemic events like oxidative stress, dysregulation of iron homeostasis, hypercoagulability and thrombus formation, acute respiratory distress syndrome, uncontrolled inflammation and organ failure (251257) (Figure 8)