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Over a median follow-up of 4 years, the primary endpoint of death from cardiovascular causes, MI, or stroke occurred in 12.2% of patients treated with tirzepatide and 13.1% of patients treated with dulaglutide, a difference that met statistical criteria for noninferiority ( P = 0.003) but not superiority ( P = 0.09)
Tirzepatide is sold under brand names Mounjaro and Zepbound
The adjusted hazard ratio (HR) for NAION in semaglutide users was 4.28
& Prudent, J
Results are broadly comparable, though direct head-to-head trials have not yet been published
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