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3 Metabolic and Cardiovascular Health : Enhanced fat metabolism 2 , potentially improved insulin sensitivity (though GH can be insulin-antagonizing, requiring monitoring), and suggested benefits for fuel homeostasis and cardiovascular health
Several factors influence DPP-4 activity: Genetics: Polymorphisms in the DPP4 gene affect enzyme expression and activity Metabolic status: Insulin resistance correlates with elevated DPP-4 activity Inflammation: Chronic inflammation increases DPP-4 expression Age: DPP-4 activity tends to increase with aging Diet composition: Certain dietary patterns modulate DPP-4 expression This variability explains why some people maintain better natural GLP-1 levels than others, even with similar L-cell activation strategies
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Nrf2, nuclear factor erythroid-2
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