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SAM levels were decreased, but S-adenosylhomocysteine (AdoHcy, SAH) levels were elevated considerably, with global DNA hypomethylation observed in both heterozygotes and homozygotes 38

Enhanced membrane translocation of protein kinase C (i.e., activation) provides a potential mechanism for diacylglyceride-induced insulin resistance, suggesting hepatic diacylglyceride to be a relevant predictor of insulin resistance in NAFLD [72, 73]

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This mechanism is a cornerstone in understanding how semaglutide aids in weight loss