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In our model, depletion of Hypoxia-Inducible Factor 1 alpha (HIF-1) impaired the effects of Exendin-4 on glucose metabolism, while pharmacological inhibition of Phosphoinositide 3-kinase (PI3K) or mTOR completely abolished such effects

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Recent analyses have raised questions about psychiatric side effects, particularly mood changes and anxiety. Patients with asthma may be at increased risk of respiratory complications, and nutrient deficiencies can occur with long-term therapy. Monitoring mental health and nutritional status should be part of any GLP-1 program

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Specifically, after RYGB, GLP-2 levels rose by 91% compared to the control group ( P = 0.02) [20]