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In the JAMA paper: expression of the GLP-1 receptor in the human optic nerve and GLP-1 RAinduced enhanced sympathetic nervous system activity might influence optic nerve head perfusion. =Rapid lowering of blood glucose (and rapid change in metabolic state) in persons with pre-existing retinopathy may worsen ocular microvascular conditions (though this is more established with insulin rather than semaglutide specifically)
So, for example, you might choose to start a NAD+ supplement if theyre focusing on boosting energy levels, improving metabolic function, or addressing age-related cellular decline
While IGF-1 plays a role in muscle repair and satellite cell activation, outcomes depend on nutrition, recovery, hormonal balance, and overall health
Psychopharmacology 240 , 12871298 (2023)
This indicates that some inhibitors might even counteract desired therapeutic effects due to their off-target activities (Dirice et al
