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Supplements safety and efficacy can differ among individuals

The comparison below draws from each drug's respective Phase 3 data

Among the companies drawing attention are T3 Defense Inc

Oliva S, Di Nardo G, Ferrari F, Mallardo S, Rossi P, Patrizi G, Cucchiara S, Stronati L: Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis

UK-licensed hydroxocobalamin injections are typically preservative-free single-use preparations, but it's always advisable to check the specific product's SmPC for excipient information if you suspect a sensitivity