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The chronic activation of this inflammatory pathway compromises astrocyte process adaptability, leading to disrupted metabolic homeostasis manifested as glucose intolerance and hypertension 24

Substances that contain NAM, or which can be converted into NAM in the body, are categorized as niacin equivalents

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Taken together, our data suggested an obvious reduction in carnitine bioavailability in individuals with higher TMAO productivity, probably because a considerable portion of ingested carnitine was consumed and converted to TMA by the gut microbiota (Fig

Primary antibodies are detailed in Supplementary Table S2