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Importantly, our studies revealed that upregulated Rab7 activity can bypass pharmacological NPC1 inhibition and activate alternative cholesterol export pathways in the human neuroblastoma SH-SY5Y cell line
S2CID 29358674
You may know free radicals for their role in causing cell damage leading to disease like Alzheimers and cancer
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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
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