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[30] [31] [32] The first and rate-limiting step in the AAA pathway is the condensation reaction between acetyl-CoA and ketoglutarate catalysed by homocitrate-synthase (HCS) (E.C 2.3.3.14) to give the intermediate homocitrylCoA, which is hydrolysed by the same enzyme to produce homocitrate
They work by quenching free radicals, compounds that cause unwanted cellular reactions
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Inflammatory bowel disease: an overview of immune mechanisms and biological treatments
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