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The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin
Fat takes the longest to digest and is most likely to trigger nausea when gastric emptying is delayed
Then everything else
The primary endpoint is the proportion of participants achieving a clinically meaningful response, defined by weight loss and/or reduction in hyperphagia
5a), confirming successful genome editing via LNP-mediated HITI
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